The advantages of array-based karyotyping are many and vary somewhat depending on what kind of array is used, but they include high-resolution, genome-wide copy number assessment in one assay a permanent, numeric result that does not fade over time like the fluorescent signals of FISH the ability to karyotype formalin-fixed paraffin-embedded tissues and the simultaneous capture of loss-of-heterozygosity (LOH) status if using a single-nucleotide polymorphism (SNP)-based array. Array-based karyotyping is gaining acceptance as a clinical tool, and physicians should be prepared to judiciously interpret results from these platforms. 1 present atypical 11q deletions identified by array-based karyotyping of chronic lymphocytic leukemia (CLL) that may be missed by FISH panels used for prognostic stratification of this disease. Array-based karyotyping is a powerful new technique for assessing chromosomal copy number changes that provides information not previously obtainable by fluorescent in situ hybridization (FISH) or conventional cytogenetics-which can be both a blessing and a challenge.
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